Which type of device should be used for testing?
Question 15
PICO (Population, Intervention, Comparison, Outcome): Should a point-of-care testing method be used to screen for hypoglycaemia in neonates?
Recommendation
Testing should use a validated and reliable point-of-care device using a glucose oxidase, glucose dehydrogenase or hexokinase method with electrochemical or amperometric detection. [Strong recommendation]
Justifications
Using more reliable testing methods is essential for accurate diagnosis and treatment. It can also reduce the number of heel pricks and is cost saving.
The common practice of using a less accurate device, with confirmation of low glucose concentrations using a more accurate device, is NOT appropriate as it does not address the problem of false negative tests (13-30%), potentially delays treatment, and increases costs.
The panel considered that recommending more reliable devices was essential to drive improvements in equity and resource allocation, leading to long-term cost savings despite potentially initial higher costs.
Implementation considerations
Examples of currently available devices meeting these requirements include Elite XL, iSTAT, Freestyle, and ABL 800.
Monitoring and evaluation
A list of currently available devices that are appropriate for neonatal blood glucose testing should be made widely available and updated regularly.
Research priorities
Nil.
Health equity
It is essential that appropriate analysers are available in all settings where newborn babies are cared for, including in primary units, to avoid potentially widening health inequities.