Are babies given formula less likely to develop neonatal hypoglycaemia?

Question 10

PICO (Population, Intervention, Comparison, Outcome): Should formula vs. control be used for preventing neonatal hypoglycaemia?

Recommendation

Formula should not be given to at-risk babies to prevent neonatal hypoglycaemia. [Conditional recommendation]

Justifications

Very low certainty of evidence shows uncertain effect on of formula on the prevention of neonatal hypoglycaemia, fully breastfeeding at hospital discharge or length of hospital stay, and uncertain effects on blood glucose concentrations.

Implementation considerations

Whānau should be provided with breastfeeding support, particularly for at-risk babies, ensuring that breastfeeding is promoted as the first line of prevention for neonatal hypoglycaemia. Implementation should account for cultural preferences and the importance of breastfeeding in different communities.

Monitoring and evaluation

Nil.

Research priorities

Studies are needed on:

  • Effectiveness of formula feeding in preventing neonatal hypoglycaemia. 

Health equity

Health equity for Māori

Health professionals must apply this guideline equitably to prevent harm and ensure accountability in implementing recommendations for Māori as part of a pro-equity approach. Pākehā benefit from health system privileges, while Māori face systemic racism, leading to reduced health benefits. Health equity can be improved if Māori receive effective interventions.

Ensure Māori whānau are fully informed about their healthcare options as a part of a mana motuhake (self-determination), including prevention, monitoring and treatment options, health benefits and potential risks. Detailed explanations of all interventions, their necessity, and results should also be provided to help achieve equitable health outcomes. Ensure whānau are provided with information in multiple formats (oral, written, online, video) that align with cultural values.

Whānau living in rural areas may face additional financial costs and barriers to accessing specialist services. Proactively support these whānau by informing and supporting them to access available financial assistance and resources to access specialist services.

Health equity for other groups

Health professionals must apply this guideline equitably to prevent harm. Health equity can be improved if all whānau receive effective interventions.

Many groups, including Pacific, Asian, migrant and rural communities, also face significant health inequities. These groups often encounter barriers such as language difficulties, lower health literacy, and challenges in understanding their healthcare options. It is important that all whānau are fully informed about their healthcare options, including prevention, monitoring and treatment options, health benefits and potential risks. Detailed explanations of all interventions, their necessity, and results should also be provided to help achieve equitable health outcomes. Culturally appropriate communication, use of interpreter services where required, along with the use of multiple formats (oral, written, online, video), can help improve engagement with health services.

Rural communities may also experience additional challenges, such as increased travel costs and limited access to specialist care. Providing proactive support, including information about and assistance to access financial and other resources to help access specialist services, is crucial to reducing these inequities and improving health outcomes. Specific additional issues are addressed under the recommendations and EtDs where relevant.