Determine the efficacy of growth hormone receptor antagonism in hepatocellular carcinoma spheroid culture models
Masters/PhD Project
Hepatocellular carcinoma (HCC) is an aggressive and difficult to treat cancer with poor survival rates and limited systemic treatment options for advanced-stage disease. The growth hormone (GH) axis has been implicated in the progression of HCC, and this has led to the suggestion that GH receptor (GHR) antagonists may have application as anti-cancer therapeutics.
Our research group has developed a series of GHR antagonists. The aim of this study is to determine the efficacy of the GHR antagonists in HCC treatment using spheroid culture models.
This project can be undertaken as a Masters by Research. It will be co-supervised by Dr Yue Wang and Associate Professor Jo Perry.
Desired skills
- Bachelors or Masters degree in biomedical science, pharmacology, biochemistry or related.
- Background knowledge in medical science (e.g. cancer biology) or protein/peptide science.
- Some experience in laboratory techniques such as pipetting, sample preparation, gel electrophoresis and plate-based assays.
Funding
Partial scholarships may be available for suitable candidates.
Contact and supervisors
For more information or to apply for this project, follow the link to the supervisor below:
Co-supervisor
Co-supervisor
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